A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates.

نویسندگان

  • Joseph Feingold
  • Theresa M Desrochers
  • Naotaka Fujii
  • Ray Harlan
  • Patrick L Tierney
  • Hideki Shimazu
  • Ken-Ichi Amemori
  • Ann M Graybiel
چکیده

A major goal of neuroscience is to understand the functions of networks of neurons in cognition and behavior. Recent work has focused on implanting arrays of ∼100 immovable electrodes or smaller numbers of individually adjustable electrodes, designed to target a few cortical areas. We have developed a recording system that allows the independent movement of hundreds of electrodes chronically implanted in several cortical and subcortical structures. We have tested this system in macaque monkeys, recording simultaneously from up to 127 electrodes in 14 brain regions for up to one year at a time. A key advantage of the system is that it can be used to sample different combinations of sites over prolonged periods, generating multiple snapshots of network activity from a single implant. Used in conjunction with microstimulation and injection methods, this versatile system represents a powerful tool for studying neural network activity in the primate brain.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Innovative Methodology A system for recording neural activity chronically and simultaneously from multiple cortical and subcortical regions in nonhuman primates

Joseph Feingold,* Theresa M. Desrochers,* Naotaka Fujii,* Ray Harlan, Patrick L. Tierney, Hideki Shimazu, Ken-ichi Amemori, and Ann M. Graybiel McGovern Institute for Brain Research, Harvard-MIT Division of Health, Sciences and Technology, and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts; Brain Science Institute, RIKEN, Saitama, Japan; Specialty ...

متن کامل

Ii : a System for Recording Neural Activity Chronically and Simultaneously from Multiple Cortical and Subcortical Regions

Beta band (13-30 Hz) oscillations in sensorimotor cortex are associated with motor performance, but the nature of this relationship is not clear. Recently, excessive beta activity in cortico-basal ganglia circuits has been recognized as a hallmark of Parkinson's disease. Renewed interest in beta oscillations has since led to the suggestion that they might reflect the preservation of the current...

متن کامل

A non-invasive head-holding device for chronic neural recordings in awake behaving monkeys.

BACKGROUND We have developed a novel head-holding device for behaving non-human primates that affords stability suitable for reliable chronic electrophysiological recording experiments. The device is completely non-invasive, and thus avoids the risk of infection and other complications that can occur with the use of conventional, surgically implanted head-fixation devices. NEW METHOD The devi...

متن کامل

Different Profiles of Verbal and Nonverbal Auditory Impairment in Cortical and Subcortical Lesions

A B S T R A C T Introduction:We investigated differential role of cortical and subcortical regions in verbal and non-verbal sound processing in ten patients who were native speakers of Persian with unilateral cortical and/or unilateral and bilateral subcortical lesions and 40 normal speakers as control subjects. Methods: The verbal tasks included monosyllabic, disyllabic dichotic and diotic tas...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of neurophysiology

دوره 107 7  شماره 

صفحات  -

تاریخ انتشار 2012